RELATION BETWEEN LUMBAR DEGENERATIVE DISC DISEASE AND HUMAN 8-HYDROXYDEOXYGUANOSINE (8-OHDG) SERUM LEVEL

J Turk Spinal Surg 2018;29(1):1-3

1. Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine, PhD, Istanbul

2. Yeditepe University, Faculty of Medicine, Department of Neurosurgery, Assistant Professor, Istanbul

3. Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine, Msc, Istanbul

4. Yeditepe University, Faculty of Medicine, Department of Medical Biology, Professor, Istanbul

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Received Date: 11.09.2017

Accepted Date: 24.11.2017

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ABSTRACT

Aim:

Lumbar degenerative disc disease (LDDD) identified as multifactorial, irreversible and degenerative discopathy. The 8-hydroxy-2 deoxyguanosine (8-OHdG) is a nucleoside oxidation of DNA marker of oxidative stress. Present study aim to investigate 8-OHdG levels in patient with LDDD as a marker of oxidative stress.

Material and Methods:

The study group included 45 patients with LDDD and 49 healthy individuals for control group. Patients with LDDD were examined with lumbar Magnetic Resonance Imaging (MRI), Oswestry Disability Index (ODI) scores, Visual Analoge Scale (VAS) scores and neurogical examination. Serum 8-OHdG levels determined with The Enzyme-Linked Immunosorbent Assay (ELISA) method.

Results:

Patients with LDDD had significantly increased levels of 8-OHdG than healthy control group (p<0.0001). Also there was positive correlation between Oswestry and VAS parameters and 8-OHdG serum levels (p<0.0001).

Conclusion:

In this study evaluated the 8-OHdG serum levels in the risk of LDDD. Increased 8-OHdG serum levels were having negative impact on severity of LDDD.

Keywords:

8-OHdG, Lumbar degenerative disc disease, oxidative damage