EFFECTS OF ETOFENAMATE AND METHYLPREDNISOLONE ON SPINAL CORD INJURY

J Turk Spinal Surg 2015;26(4):275-282

1. MD, Assistant Professor of Neurosurgery, Neurosurgery Department, Dr Ridvan Ege Hospital, Medical School of Ufuk University, Ankara.

2. MD, Professor of Neurosurgery, Neurosurgery Department, Research and Training Hospital, Medical School, Duzce University, Duzce.

3. MD, Associated Professor of Neurosurgery, Neurosurgery Department, Dr Ridvan Ege Hospital, Medical School of Ufuk University, Ankara.

4. MD, Associated Professor of Neurosurgery, Neurosurgery Department, Kartal Research and Training Hospital, Istanbul.

No information available.

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Received Date: 12.07.2015

Accepted Date: 27.08.2015

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ABSTRACT

This study evaluates the effects of etofenamate on secondary damage following a spinal cord injury and compares the effects with those of methylprednisolone. A total of 31 male Wistar-Albino rats were used. A weight-drop model was utilized for the experimental spinal cord injury and a 50g-cm impact was applied on the spinal cord. Rats were randomly assigned to one of the three study arms (saline, etofenamate 20 mg/kg, methylprednisolone 30 mg/kg). At the sixth hour of injury electrophysiological evaluations were conducted under anesthesia, and then rats were sacrificed for histopathology. Hematoxylin and eosin staining were applied to the specimens and evaluated under light microscopy. Etofenamate revealed more beneficial results in histopathological evaluations when compared with methylprednisolone, but these favorable results have not been confirmed by electrophysiological measurements. Etofenamate may be a promising agent in the medical treatment of spinal cord injury.