Review

DEGENERATIVE DISC DISEASE AND GENETIC

  • Ramazan KAHVECI
  • Hüseyin ÖZEVREN
  • Ergün KARAVELIOĞLU

Received Date: 01.11.2014 Accepted Date: 11.12.2014 J Turk Spinal Surg 2015;26(1):67-78

Although development of the intervertebral disc disease is a multifactorial condition, recent studies associated with genes playing a role in disc dejeneration revealed that the importance of the genetic factors in the development of disc disease. Our purpose of this study is to review current knowledge on genes associated with intervertebral disc degeneration.

Keywords: degenerative disc disease, aggrecan, collagene, vitamin D receptor, interleukin, ADAMTS, matrixmetalloproteinase